HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → Carnosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 1,3-thiazinane-2,4-dione | HCID 2304067 | — |
| Reactant | Tetrabutylammonium Hydroxide | HCID 2723671 | — |
| Reactant | HCID 178419078 | HCID 178419078 | — |
| Product | Carnosine | HCID 439224 | 79.6% |
Reaction Steps
Following the procedure of Example 1., 1.55 g. (10 mmol) of L-histidine and 2.62 g. (20 mmol) of tetrahydro-1,3-thiazin-2,4-dione were reacted, using 40% aqueous tetra-n-butylammonium hydroxide solution to raise pH and methanesulfonic acid to lower pH, to give 1.80 g. (79.6% yield) of L-carnosine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04359416 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-7cf1111d6d6d41fe879bb6ca67c8ac47 |
| Source note | uspto-grants-1982_11 |