Hydroxylamine → HCID 72307471, compound

Participants

Reaction Steps

Methyl 4-cyano-2-fluoro-5-methoxybenzoate (64 mg; 0.31 mmol; 1 eq.) was dissolved in MeOH. Hydroxylamine (90.23 μl; 1.53 mmol; 5 eq.) was added and the mixture was stirred at RT overnight. As the reaction was not complete, it was heated at 50° C. for one more day. The solvents were then evaporated, affording the title product as an orange oil, which was used without further purification (74 mg; 100%). LC/MS (Method B): 243.1 (M+H)+. HPLC (Method A) Rt 1.24 min (Purity: 80.3%).

Provenance & Evidence