Methanol → Methyl 4-bromo-2-chloro-5-fluorobenzoate

Participants

Reaction Conditions

Reaction Steps

4-bromo-2-chloro-5-fluorobenzoic acid (Apollo PC9723, 5 g; 19.73 mmol; 1 eq.) was dissolved in MeOH (100 mL). The solution was cooled down to 0° C. SOCl2 (4.29 mL; 59.18 mmol; 3 eq.) was added dropwise (addition took 15 min and IT increased to 9° C.). The reaction mixture was stirred at RT for 2 days. The reaction mixture was concentrated and the crude mixture was dissolved in EtOAc (100 mL) and washed with a saturated aqueous solution of NaHCO3(30 mL) and brine (30 mL), dried over MgSO4 and concentrated under vacuum affording the title compound as a white powder (5.26 g, 99%), 1H NMR (DMSO-d6, 300 MHz) δ 8.10-8.08 (d, J=6.28 Hz, 1H), 7.86-7.83 (d, J=8.63 Hz, 1H), 3.87 (s, 3H). HPLC (Method A) Rt 4.32 min (Purity: 99.6%).

Provenance & Evidence