HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-[3-(4-oxo-piperidino)-propyl]-benzimidazolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 1810419 | — |
| Product | N-[3-(4-oxo-piperidino)-propyl]-benzimidazolone | HCID 13056043 | 39% |
Reaction Steps
A mixture of 6.3 gm of N-(3-chloropropyl)-benzimidazolone, 4.6 gm of 4-piperidine hydrochloride monohydrate, 5.0 gm of sodium bicarbonate, 50 ml of tetrahydrofuran, and 50 ml of dimethylformamide, was heated to reflux, for 36 hours. The product was worked up as usual, yielding 3.2 gm (39% of theory) of N-[3-(4-oxo-piperidino)-propyl]-benzimidazolone, m.p. 134°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04359468 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-c7cda93a885741f5b525aa2c0befd1ea |
| Source note | uspto-grants-1982_11 |