Tetrahydrofuran → HCID 13056032, compound

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Reaction Steps

0.5 gm of the above intermediate were dissolved in 5 ml tetrahydrofuran and added to a cooled suspension of N-isopropenyl-benzimidazolone sodium salt prepared from 0.34 gm of N-isopropenyl-benzimidazolone and 0.05 gm of sodium hydride in 5 ml of dimethylformamide. The mixture was stirred for 16 hours at room temperature and then poured on ice-water-ammonia. The crystalline product was filtered off and dried. Yield: 0.65 gm (81% of theory), m.p. 68° C., identical with the product obtained by method B in Example 6.

Provenance & Evidence