Diethyl Ether → 1-Bromo-3,3-dimethyl-4-fluoro-2-butanone

480 g of bromine were slowly added dropwise to a mixture of 354 g (3 mols) of 3,3-dimethyl-4-fluoro-2-butanone and 2,000 ml of ether at 20° to 30° C., while cooling and stirring. The yellowish solution was subsequently stirred at 20° C. for a further hour and 500 ml of water were then carefully added. The ether phase was separated off, washed several times with water and dried over sodium sulphate. After distilling off the solvent, the residue was distilled under a waterpump vacuum. 472 g (80% of theory) of 1-bromo-3,3-dimethyl-4-fluoro-2-butanone of boiling point 80°-90° C./11 mm Hg were obtained. ##STR81##

1. temperaturewhile cooling
2. stirringThe yellowish solution was subsequently stirred at 20° C. for a further hour
3. customThe ether phase was separated off
4. washwashed several times with water
5. dry with materialdried over sodium sulphate
6. distillationAfter distilling off the solvent
7. distillationthe residue was distilled under a waterpump vacuum

ORD record

ord-90c1fbefb3894152b8f4c1805705bb4a

Source dataset

uspto-grants-1982_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04359470