Ethanol → HCID 13064593, compound

Participants

Reaction Steps

A mixture of 9.3 g. of N'-(4-amino-2,6-dichlorophenyl)-N,N-dimethylformamidine (Example 9) and 6.9 g. of m-trifluoromethylbenzaldehyde in 25 ml. of absolute ethanol is refluxed for 18 hours. The solution is evaporated in vacuo to give a syrup. The syrup is extracted into hot heptane. The solvent is evaporated to provide an oil. The oil is dissolved in chloroform and the solution is filtered through a magnesium silicate column packed with chloroform. The column is washed with chloroform until the wash is colorless. The filtrate is evaporated to give a yellow syrup which crystallizes on cooling. The product is recrystallized from n-hexane to give 8.3 g. of the product of the Example as granular yellow crystals, m.p. 62°-64° C.

Provenance & Evidence