HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthol → Propranolol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthol | HCID 7005 | — |
| Reactant | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| Product | Propranolol | HCID 4946 | — |
Reaction Steps
1-(isopropyl)-3-azetidinol and α-naphthol were reacted in the same manner as in Example 6 to form 1(-α-naphthoxy)-3-(iso-propylamino)-2-propanol. Then the propanol was dissolved in anhydrous ether and was converted to a hydrochloride by blowing a hydrochloric acid gas into the resulting solution. As a result, 1-(α-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride melting at 162°-164° C. was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04360464 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-6e6349ee2cee42d489856d17ebc4f5d6 |
| Source note | uspto-grants-1982_11 |