1-Naphthol → 1-(alpha-Naphthoxy)-2-benzyloxy-3-(iso-propylamino)-propane

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6.2 parts of 1-(iso-propyl)-3-benzyloxyazetidine and 43 parts of α-naphthol 1.5 parts of sodium hydroxide was added, and the mixture was heated at 200° C. for 16 hours. The reaction mixture was cooled, and 100 parts of ether were added thereto. Excessive α-naphthol was removed by extraction with 2 N-sodium hydroxide aqueous solution. The remaining ether layer was washed in water and dried over anhydrous sodium sulfate. After distillation of ether, the residue was subjected to distillation to yield 8.3 parts of 1-(α-naphthoxy)-2-benzyloxy-3-(iso-propylamino)-propane boiling at 192°-195° C. The yield was 79%.

Provenance & Evidence