HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6,7,8-Tetrahydro-1-naphthol → Nadolol EP Impurity G
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6,7,8-Tetrahydro-1-naphthol | HCID 68258 | — |
| Reactant | 1-tert-Butyl-3-hydroxyazetidine | HCID 287986 | — |
| Product | Nadolol EP Impurity G | HCID 12445684 | — |
Reaction Steps
1-(tert.-butyl)-3-azetidinol and 5,6,7,8-tetrahydro-α-naphthol were reacted in the same manner as in Example 1 to form 1-(5,6,7,8-tetrahydro-α-naphthoxy)-3-(tert.-butylamino)-2-propanol. A hydrochloric acid gas was blown into the obtained propanol. As a result, 1-(5,6,7,8-tetrahydro-1-naphthoxy)-3-(tert.-butylamino)-2-propanol hydrochloride having a melting point of 148°-150° C. was obtained. The yield was 70%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04360464 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-abfdb92325554b9a88fd93dec0f886c5 |
| Source note | uspto-grants-1982_11 |