反应详情

温度

40 °C

A solution of 4.4 parts of 3-benzyloxy-1-(tert.-butyl)azetidine in 30 parts of ethanol was added to an autoclave together with 2 parts of Raney nickel as catalyst. Under a hydrogen gas pressure of 100 atmospheres, the mixture was stirred at 40° C. for 15 hours to perform the reduction. The catalyst was separated by filtration, and the remaining ethanol solution was concentrated to dryness. The resulting oily substance was dissolved in n-hexane and cooled. As a result 2.0 parts of 1-(tert.butyl)-3-azetidinol melting at 42°-43° C. The yield was 76%. The results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:

1. customThe catalyst was separated by filtration
2. concentrationthe remaining ethanol solution was concentrated to dryness
3. dissolutionThe resulting oily substance was dissolved in n-hexane
4. temperaturecooled