HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(6'-Methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(Propan-2-yl)azetidin-3-ol | HCID 544677 | — |
| Reactant | 6-methoxy-1-naphthol | HCID 11008416 | — |
| Product | 1-(6'-Methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride | HCID 20517328 | 57.5% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A mixture of 9.5 parts of 6-methoxy-1-naphthol, 5.8 parts of 1-(iso-propyl)-3-azetidinol and 0.3 part of potassium hydroxide was heated under nitrogen gas at 140° C. for 8 hours with agitation. The reaction mixture was treated in the same manner as in Example 1, and when the resulting hydrochloride was recrystallized from iso-propyl alcohol, there was obtained 17.7 parts of 1-(6'-methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride melting at 165°-167° C. The yield was 57.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04360464 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-fcb9b6a501674d728eedab02ca126fdd |
| Source note | uspto-grants-1982_11 |