HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1′-Methylspiro[benzothiazole-2(3H),4′-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2-Aminothiophenol | HCID 8713 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1′-Methylspiro[benzothiazole-2(3H),4′-piperidine] | HCID 2826310 | — |
Reaction Steps
A mixture of 125.5 g 2-amino-thiophenol, 147 g N-methyl-4-piperidone, 2 ml acetic acid and 400 ml toluene is refluxed with a water separator for 2 hours. The mixture is evaporated in vacuo. The residue is recrystallised from methylene chloride/ether/petroleum ether to give the heading compound, m.p. 135°-140°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04360525 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-b5f81450be074655967b563b4a334c20 |
| Source note | uspto-grants-1982_11 |