HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 20517713, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Reactant | 5-Chloro-2-fluorobenzoyl chloride | HCID 2773604 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 20517713 | HCID 20517713 | — |
Reaction Steps
A mixture of 23.9 g 4-amino-1-methyl-piperidine, 48.5 g 5-chloro-2-fluoro-benzoyl chloride, 44 ml triethylamine and 550 ml benzene is refluxed for 2 hours. Thereafter the solvent is evaporated off in vacuo and the residue is added dropwise under stirring to water. The solution is made alkaline and extracted with toluene. The toluene phase is dried and evaporated. The residue is recrystallised from methylene chloride/ether/petroleum ether to give the heading compound, m.p. 143°-145°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04360525 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-eff5fecb943f4873b3f16d8ca3fa0b43 |
| Source note | uspto-grants-1982_11 |