Hydrogen Bromide → Hydrogen Bromide

Participants

Reaction Steps

2-Ethyl-2-(3-methoxyphenyl)-4,6-dimethylmorpholine (7.0 g) was refluxed for 2.5 hours with aqueous 48% hydrobromic acid (50 ml). After removal of the solvent under reduced pressure the residue was re-evaporated using isopropyl alcohol to remove last traces of HBr and water. Fractional crystallisation of the residue (10.5 g) from isopropyl alcohol/ether gave 1.53 g of 95% stereochemically pure title compound isomer A hydrobromide (m.p. 241°-5° C.).

Provenance & Evidence