Sodium Hydroxide → HCID 20517509, compound

Participants

Reaction Steps

The above mixture of isomers of 6-(3-methoxyphenyl)-2,4,6-trimethyl-3-morpholinone (15.8 g) in dry ether (50 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (4.0 g) in ether (250 ml). After heating under reflux for 3 hours the reaction mixture was cooled and the complex decomposed by the cautious, successive addition of water (4 ml), 2 M sodium hydroxide (8 ml) and anhydrous MgSO4. The inorganic material was filtered off and the filtrate removed under reduced pressure affording 15 g of oil.

Provenance & Evidence