Potassium sodium tartarate → HCID 20517506, compound

HRID 2198889Notes

Reaction equation

HRID 2198889 reaction equation
[CH2:1]([C:3]1([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[CH2:8][NH:7][C:6](=O)[CH:5]([CH3:10])[O:4]1)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>CCOCC.O>[CH2:1]([C:3]1([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[O:4][CH:5]([CH3:10])[CH2:6][NH:7][CH2:8]1)[CH3:2]

Participants

6

Reactant 3

HCID 9855836Potassium sodium tartarateHCID 20517546HCID 20517546, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 20517506HCID 20517506, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent2×

Procedure

The crude 6-ethyl-6-(3-methoxyphenyl)-2-methyl-3-morpholinone was added in ether to a cooled suspension of lithium aluminium hydride (12 g) in ether and then refluxed for 6 h. A solution of potassium sodium tartrate (132 g) in water (300 ml) was slowly added to the cooled suspension. The ether layer was washed and dried giving the title compound as a yellow oil (12.3 g). Both this and the parent morpholinone were mixtures of equal proportions of diastereoisomers in >95% purity.

Workup

  1. temperaturerefluxed for 6 h
  2. washThe ether layer was washed
  3. customdried

Sources & evidence

ORD record
ord-41f472cf2d4c46ba9625db3da0fc0754
Source dataset
uspto-grants-1982_11
Patent number
US04360519

Reaction notes

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