Hydrogen Bromide → HCID 20517530, compound

Participants

Reaction Steps

2-Ethyl-2-(3-methoxyphenyl)-4-methyl-6-phenylmorpholine hydrochloride (Isomer B from Example 22) (607 mg) was heated under reflux with concentrated hydrobromic acid (5 ml) for 1.25 h. On cooling crystals and a dark gum separated. The hydrobromic acid was removed under reduced pressure and the gummy product re-evaporated with portions of isopropyl alcohol. The product was recrystallised from isopropyl alcohol to give the title compound of apparently 2R*,6S* configuration (422 mg), mp 250°-252° C.

Provenance & Evidence