Sodium metaborate → HCID 54298650, compound

HRID 2198900Notes

Reaction equation

HRID 2198900 reaction equation
B([O-])=O.[Na+].[N:5]1([CH:10]=[C:11]([O:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[C:12](=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[CH:9]=[CH:8][N:7]=[CH:6]1>CO>[N:5]1([CH:10]=[C:11]([O:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[CH:12]([OH:17])[C:13]([CH3:16])([CH3:15])[CH3:14])[CH:9]=[CH:8][N:7]=[CH:6]1

Participants

4

Reactant 2

HCID 145326Sodium metaborateHCID 54455995HCID 54455995, compound

Product 1

HCID 54298650HCID 54298650, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

12.4 g (0.33 mols) of sodium boranate were introduced in portions into a solution of 98.8 g (0.33 mols) of 1-(imidazol-1-yl)-2-(4-chlorophenoxy)-4,4-dimethyl-1-penten-3-one in 1,000 ml of methanol at 20° to 30° C. in the course of 30 minutes, with slight external cooling. After 3 hours, the solution was filtered and the filtrate was acidified with 10% strength acetic acid and evaporated under reduced pressure. The solid residue which remained was stirred into 1.3 liters of water. The water-insoluble reduction product was filtered off and dried at 50° C. in vacuo. 93.7 g (92.55% of theory) of 1-(imidazol-1-yl)-2-(4-chlorophenoxy)-4,4-dimethyl-1-penten-3-ol of melting point 141°-143° C. were obtained in the form of colorless crystals.

Workup

  1. filtrationthe solution was filtered
  2. customevaporated under reduced pressure
  3. filtrationThe water-insoluble reduction product was filtered off
  4. customdried at 50° C. in vacuo

Sources & evidence

ORD record
ord-501cd2803ae34c63b01da800afd7251e
Source dataset
uspto-grants-1982_11
Patent number
US04360528

Reaction notes

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