5-Fluorouracil → 5-Fluorouracil

HRID 2198966Notes

Reaction equation

HRID 2198966 reaction equation
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[OH-].[K+].[N+]([O-])([O-])=O.[Ag+:16]>O>[Ag:16].[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1

Participants

6

Reactant 3

HCID 33855-FluorouracilHCID 14797Potassium HydroxideHCID 24470Silver Nitrate

Product 2

HCID 33855-FluorouracilYield 93.4%HCID 23954Silver

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In 5 ml. of distilled water, 100 mg. of 5-fluoro-2,4-dioxo-pyrimidin (5-Fu) was dispersed and then KOH aqueous solution (10 ml. of water; 50.8 mg. of KOH) was slowly added. After the addition, the mixture was stirred for 30 minutes to form a transparent solution having pH of 8 to 9 and then 2.6% aqueous solution of AgNO3 was added dropwise and the mixture was stirred for 1 hour in the dark. The precipitate was separated by a filtration and washed with water and dried under a reduced pressure to obtain silver salt of 5-Fu (yield: 93.4%).

Workup

  1. additionAfter the addition
  2. customto form a transparent solution
  3. stirringthe mixture was stirred for 1 hour in the dark
  4. customThe precipitate was separated by a filtration
  5. washwashed with water
  6. customdried under a reduced pressure

Sources & evidence

ORD record
ord-22512c42e44f43d2b3b4903418cba802
Source dataset
uspto-grants-1982_11
Patent number
US04360663

Reaction notes

Loading…