1-(2-Methoxyphenyl)piperazine → HCID 20452286, compound

Participants

Reaction Steps

2.6 g (0.013 mole) of 97% 1-(2-methoxyphenyl)-piperazine and 1.3 g (0.013 mole) of ground KHCO3 are added to a solution of 2.93 g (0.012 mole) of 2-(2-chloroethyl)-1-methyl-1H-naphth[1,2-d]imidazole in 100 cc of anhydrous alcohol, maintained under an argon atmosphere. The obtained reaction mixture is refluxed with stirring under argon, and three 1.3 g portions of 97% 1-(2-methoxyphenyl)piperazine are added at the 23rd, 30th and 43rd hour of refluxing. After 50 hours, the solvent is evaporated and the residue is taken up with a small amount of water, filtered and dried, yielding 5.1 g of raw material. Crystallization from a mixture of 160 cc of water and 140 cc of ethanol affords 4.55 g of pure compound melting at 154°-55° C. (Yield 90%)

Provenance & Evidence