Trichloroethylene → HCID 86738644, compound

Participants

Reaction Conditions

Reaction Steps

3.3 g of 1,6-dipalmitoyl-D-mannitol and 0.53 of benzene boronic acid anhydride was added to a solution containing 20 ml of pyridine and 20 ml of trichloroethylene, and the mixture was dried with 5 g of molecular sieves. The mixture was cooled at -18° C. and 3.3 g of oleoyl chloride, dissolved in 10 ml of trichloroethylene, was added. The mixture was left standing over night at -18° C. and for four hours at room temperature. The reaction mixture was washed with 120 ml of 2 N hydrochloric acid and with water, and fractionated in a column containing 160 g of Sephadex LH 20 and eluting with a 1:1-mixture of chloroform and ethanol (90%), whereby the boronic acid protection was removed.

Provenance & Evidence