3-[(2-Hydroxyethoxy)methyl]benzonitrile → N'-hydroxy-3-[(2-hydroxyethoxy)methyl]benzenecarboximidamide

Participants

Reaction Steps

The title compound was obtained following procedure and work up described for Intermediate 47 step 2 but starting from 3-[(2-hydroxyethoxy)methyl]benzonitrile obtained in step 1 (0.90 g; 5.08 mmol) to give the title compound as a yellowish oil (1.26 g, quantitative). 1H NMR (DMSO-d6, 300 MHz) δ 9.61 (s, 1H), 7.64 (bs, 1H), 7.60-7.55 (m, 1H), 7.37-7.31 (m, 2H), 5.75 (bs, 2H), 4.66-4.62 (m, 1H), 4.50 (s, 2H), 3.56-3.51 (m, 2H), 3.48-3.44 (m, 2H). LC/MS (Method B): 211.1 (M+H)+.

Provenance & Evidence