HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → N-[4-(1-Piperazinyl)butyl]-3,3-dimethylglutarimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,4-Dimethylpiperidine-2,6-dione | HCID 14292 | — |
| Reactant | 1-(4-Bromobutyl)-4,4-dimethylpiperidine-2,6-dione | HCID 13660335 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[4-(1-Piperazinyl)butyl]-3,3-dimethylglutarimide | HCID 20516935 | 85% |
Reaction Steps
A mixture of N-(4-bromobutyl)-3,3-dimethylglutarimide (20.0 g; 0.07 mole [prepared from 3,3-dimethylglutarimide using the method of Example 2]); piperazine (31.0 g; 0.36 mole); K2CO3 (29.8 g; 0.22 mole); and KI (0.1 g) was refluxed in 250 mL acetonitrile for 18 hr. The mixture was filtered, concentrated and the unreacted piperazine removed by vacuum sublimation. The residual material was distilled to yield 17.2 g (85%) product, b.p. 170°-178° C. at 0.01 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04361565 |
| Source dataset | uspto-grants-1982_11 |
| ORD ID | ord-613b4dba2a814f92b4367ed0edb4cfd4 |
| Source note | uspto-grants-1982_11 |