Piperazine → 2-(Piperazin-1-yl)pyridine-3-carbonitrile

Participants

Reaction Steps

2-Chloro-3-cyanopyridine (5.5 g; 0.04 mole) was dissolved in 80 mL ethanol (warming) and piperazine (17.2 g; 0.2 mole) was combined with this solution and the whole stirred at room temperature for 18 hrs. The reaction mixture was filtered and the filtrate concentrated to a residue which was partitioned between Et2O and H2O. The water layer was made basic and extracted with Et2O. The Et2O extracts were washed with water, dried (MgSO4), concentrated to a solid which was recrystallized from Skellysolve B to yield 3.2 g product, m.p. 102°-104° C.

Provenance & Evidence