Ethanol → HCID 20165014, compound

HRID 2199059Notes

Reaction equation

HRID 2199059 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][CH:15]3[CH2:17][CH2:16]3)=[C:10]([N+:18]([O-])=O)[CH:9]=2)=[N:6][NH:5][C:4](=[O:21])[CH2:3]1.C(O)C.[H][H]>[Pd].C(O)(=O)C>[CH3:1][CH:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][CH:15]3[CH2:16][CH2:17]3)=[C:10]([NH2:18])[CH:9]=2)=[N:6][NH:5][C:4](=[O:21])[CH2:3]1

Participants

6

Reactant 3

HCID 702EthanolHCID 20516901HCID 20516901, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20165014HCID 20165014, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent2×

Procedure

5.8 gm of 5-methyl-6-(3-nitro-4-cyclopropylamino-phenyl)-3-oxo-4,5-dihydro-2H-pyridazine were hydrogenated in a mixture consisting of 100 ml of ethanol and of 20 ml of glacial acetic acid in the presence of 0.5 gm of 10% palladium charcoal at a hydrogen pressure of 5 bar. 120 ml of glacial acetic acid were added, the catalyst was filtered off and the filtrate was evaporated in vacuo. The residue was reacted further without further purification.

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated in vacuo
  3. customThe residue was reacted further without further purification

Sources & evidence

ORD record
ord-d3bbc2d8c9c34396b4e5d3ec319efca1
Source dataset
uspto-grants-1982_11
Patent number
US04361563

Reaction notes

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