反应详情

The title compound was obtained following procedure and work up described for Intermediate 47 step 2 but starting from 3-{[(2-Hydroxy-ethyl)-methyl-amino]-methyl}-benzonitrile obtained in step 1 (4.9 g, 26.28 mmol) to give the title compound as white gummy solid (5.7 g, 99%). 1H NMR (DMSO-d6, 400 MHz) δ 9.58 (s, 1H), 7.60 (s, 1H), 7.51-7.54 (m, 1H), 7.28-7.31 (m, 2H), 5.76-7.83 (s, 2H), 4.38 (bs, 1H), 3.48-3.51 (m, 4H), 2.40-2.43 (m, 2H), 2.13 (m, 3H). LC/MS (Method A): 224.1 (M+H)+. HPLC (Method B): Rt 0.7 min, (Purity 91.1%).