HCID 22822149, compound → HCID 54383316, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 11β-hydroxy-17,17-bis-(methylthio)androsta-1,4-diene-3-one (2.6 g) in dry diethylbenzene (120 ml) is refluxed for 1.0 hour in a bath at about 200° C. The resulting solution is then cooled to room temperature and subsequently in an ice bath to afford the title compound as needles (2.1 g), after filtration and washing with hexane. The filtrate is subsequently chromatographed on a column of silica gel (30 g) to afford another 100 mg of product. The total yield is thus 2.2 g of product, melting point 240°-241° C., dec., with a consistent nmr spectrum.

Provenance & Evidence