methyl 4-(N-hydroxycarbamimidoyl)benzoate → HCID 67528376, compound

Participants

Reaction Steps

The title compound was prepared following procedure described for example 4, step 1, but starting from Intermediate 3 (113.14 mg; 0.50 mmol) and methyl 4-[amino(hydroxyimino)methyl]benzoate (Maybridge; 97.10 mg; 0.50 mmol). The reaction mixture was filtered through a SPE NH2 column (2 g) and rinsed with ACN. The filtrate was passed through a SPE SCX column (2 g) and rinsed with ACN. After evaporation of the solvents, the crude product was purified by flash chromatography (c-hex/EtOAc: 9.5/0.5), affording the title compound as a colorless oil. LC/MS (Method A): 385.0 (M+H)+. HPLC (Method A) Rt 6.16 min (Purity: 98.5%).

Provenance & Evidence