反应详情

In 30 ml of carbon tetrachloride, 1.04 g (8.13 mmol) of 2-chloro-5-methylpyrimidine was dissolved. To this solution, 1.73 g (9.75 mmol) of N-bromosuccinimide and 20 mg of benzoyl peroxide were added, followed by heating under reflux for 6 hours. After completion of the reaction, the reaction liquid was returned to room temperature, and concentrated under reduced pressure. Then, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1). Thus, 641 mg of 5-bromomethyl-2-chloropyrimidine was obtained (Percentage Yield: 380).

1. temperatureby heating
2. temperatureunder reflux for 6 hours
3. customAfter completion of the reaction
4. customthe reaction liquid
5. customwas returned to room temperature
6. concentrationconcentrated under reduced pressure
7. customThen, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=3:1)