HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 15075752, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(4-Fluorobenzoyl)benzoic acid | HCID 82099 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 15075752 | HCID 15075752 | 100% |
Reaction Steps
THF (25 mL) was added to 2-(4-fluorobenzoyl)benzoic acid (5 g, 20.4 mmol) followed by thionyl chloride (2.97 mL, 40.9 mmol) and a catalytic amount of DMF (3 drops). The system was stirred under nitrogen for 4 h at room temperature. Removal of the solvent gave 3-chloro-3-(4-fluorophenyl)-3H-isobenzofuran-1-one as a colourless oil (5.35 g, 20.4 mmol, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09358222B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-c5205afde28c47f08d7c37417f9a56b7 |
| Source note | uspto-grants-2016_06 |