反应详情

The title compound was prepared following procedure described for example 4, step 1, but starting from Intermediate 49 (142.14 mg; 0.50 mmol) and Intermediate 15 (172.37 mg; 0.60 mmol). The reaction mixture was filtered through a SPE NH2 column (2 g) and rinsed with ACN. The filtrate was passed through a SPE SCX column (2 g) and rinsed with ACN. After evaporation of the solvents, the crude product was purified by flash chromatography (c-hex/EtOAc: 9.5/0.5), affording the title compound as a white solid. LC/MS (Method B): 536.4 (M+H)+. HPLC (Method A) Rt 7.2 min (Purity: 99.4%).

1. customThe title compound was prepared following procedure
2. filtrationThe reaction mixture was filtered through a SPE NH2 column (2 g)
3. washrinsed with ACN
4. washrinsed with ACN
5. customAfter evaporation of the solvents
6. customthe crude product was purified by flash chromatography (c-hex/EtOAc: 9.5/0.5)