HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylbenzylamine → 3-(4-Chlorophenyl)-3-hydroxy-2-(4-methylbenzyl)isoindolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylbenzylamine | HCID 66035 | — |
| Reactant | 2-(4'-Chlorobenzoyl)benzoic acid | HCID 66564 | — |
| Product | 3-(4-Chlorophenyl)-3-hydroxy-2-(4-methylbenzyl)isoindolin-1-one | HCID 51349700 | 74% |
Reaction Steps
The named compound was synthesised from 2-(4-chlorobenzoyl)-benzoic acid (2.0 g, 7.6 mmol) and 4-methyl benzylamine (1.07 mL, 8.4 mmol) using General Procedure B, purified by chromatography (Biotage SP4; 10-80% EtOAc/hexane) and obtained as a white solid (2.045 g, 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09358222B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-8325d85daee14550bd8245a0b73a6f8c |
| Source note | uspto-grants-2016_06 |