反应详情

To a solution of compound 1 (300 mg, 0.96 mmol) in ethanol, 10 mg of 5% Pd/C was added. The reaction mixture was stirred for 16 h under hydrogen gas at atmospheric pressure. Pd/C was filtered, and the solvent was evaporated to dryness. Compound 11 was obtained as a white solid (285 mg, 95% yield). Rf (30:70 methanol:chloroform)=0.20. 1H NMR (300 MHz, CDCl3): δ 7.25-6.90 (m, 8H, Ar—H), 3.60-2.50 (m, 10H, NCH2CHCH2). 13C NMR (75 MHz, CDCl3): 175.10, 161.05 (d, J=250.0), 131.34 (d, J=4.3), 128.68 (d, J=8.3), 124.28 (d, J=15.5), 115.48 (d, J=21.6), 48.55, 46.54, 25.52. ESI Mass calculated for C19H20F2NO (M+H)+316.15. found 316.20.

1. filtrationPd/C was filtered
2. customthe solvent was evaporated to dryness