HCID 67528395, compound → HCID 67528662, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl 4-{5-[4-(dimethylamino)-3-nitrophenyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate obtained in step 1 (150 mg; 0.39 mmol) in EtOH (15 mL) was added stannous chloride dihydrate (438.05 mg; 1.94 mmol) and stirred at 70° C. for 3 h, then at RT for 16 h. After this time, the solution was diluted with a saturated aqueous solution of NaHCO3 (75 mL) and extracted with EtOAc (100 mL). The combined organic layers were washed with brine (50 mL), dried over magnesium sulfate and concentrated under vacuum to give the title compound. LC/MS (Method B): 357.3 (M+H)+. HPLC (Method A) Rt. 3.75 min (purity: 95.4%).

Provenance & Evidence