Allyl bromide → HCID 71626136, compound

HRID 2199488Notes

Reaction equation

[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8](/[CH:14]=[CH:15]/[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:3]=1[C:4]([O:6][CH3:7])=[O:5].[CH2:22](Br)[CH:23]=[CH2:24]>>[OH:1][C:2]1[C:11]([CH2:24][CH:23]=[CH2:22])=[C:10]([O:12][CH3:13])[CH:9]=[C:8](/[CH:14]=[CH:15]/[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

Reactant 2

HCID 7841Allyl bromide

HCID 71626584HCID 71626584, compound

Product 1

HCID 71626136HCID 71626136, compoundYield 58%

Procedure

Use Compound 7 and allyl bromide as materials, and follow the method described in Example 7 to obtain a white solid as the product (58%). 1H NMR (400 MHz, DMSO-d6): 3.22 (d, J=7.6 Hz, 2H), 3.75 (s, 3H), 3.89 (s, 3H), 4.93 (dd, J1=16.0 Hz, J2=12.0 Hz, 1H), 4.96 (dd, J1=6.4 Hz, J2=12.0 Hz, 1H), 6.30 (m, 1H), 6.70 (s, 1H), 6.82 (d, J=16.0 Hz, 1H), 7.30 (m, 2H), 7.42 (d, J=7.6 Hz, 2H), 7.48 (t, J=7.6 Hz, 2H), 9.83 (s, 1H).

Sources & evidence

ORD record: ord-58a79158f2c54900a203b0aac642d3b7
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09359298B2

Reaction notes

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