1-Propanesulfonyl chloride → Methyl 4-{5-[3-[(propylsulfonyl)amino]-4-(2-methylpiperidin-1-yl)phenyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate

Participants

Reaction Steps

The title compound was obtained following procedure and work up described for example 67, step 1, but starting from methyl 4-{5-[3-amino-4-(2-methylpiperidin-1-yl)phenyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate, prepared as in example 67, Steps 1 and 2, (200 mg; 0.49 mmol) and 1-propanesulfonyl chloride (280 mg; 2 mmol). The title compound was obtained as a yellow powder after column chromatography (EtOAc:cHex from 10:90 to 100:0). LC/MS (Method B): 517.4 (M+H)+. HPLC (Method A) Rt. 6.37 min (purity: 96.5%).

Provenance & Evidence