HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Thiosulfate → 1-(Cyclopropanesulfinyl)-4-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Thiosulfate | HCID 24477 | — |
| Reactant | Metaperiodic acid | HCID 65185 | — |
| Reactant | Cyclopropyl(4-nitrophenyl)sulfane | HCID 59252683 | — |
| Catalyst | Iron chloride (FeCl3) | HCID 24380 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(Cyclopropanesulfinyl)-4-nitrobenzene | HCID 59550834 | 76% |
Reaction Steps
1-Cyclopropylsulphanyl-4-nitrobenzene in acetonitrile was admixed with iron(III) chloride and stirred at room temperature. Periodic acid was then added in portions. The mixture was stirred for 30 minutes and then added, with stirring, to a cooled, saturated sodium thiosulphate solution. Extraction was carried out with acetic ester (2×). The combined organic phases were dried (Na2SO4), filtered and concentrated by evaporation. The residue obtained was purified by means of chromatography (hexane/acetic ester 1:1) (yield: 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359306B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-e4c157c202d54a9394c65bbcea42921b |
| Source note | uspto-grants-2016_06 |