HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetamide → N-[(R)-Cyclopropyl(4-nitrophenyl)oxidosulphanylidene]-2,2,2-trifluoroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetamide | HCID 67717 | — |
| Reactant | Magnesium monoxide | HCID 6850729 | — |
| Reactant | Iodo benzene diacetate | HCID 12217721 | — |
| Reactant | 1-(Cyclopropanesulfinyl)-4-nitrobenzene | HCID 59550834 | — |
| Catalyst | Dirhodium tetraacetate | HCID 152122 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[(R)-Cyclopropyl(4-nitrophenyl)oxidosulphanylidene]-2,2,2-trifluoroacetamide | HCID 56949254 | 78% |
Reaction Steps
A suspension of (RS)-1-cyclopropanesulphinyl-4-nitrobenzene, trifluoroacetamide, iodobenzene diacetate and magnesium oxide in DCM was admixed, under argon, with rhodium(II) acetate dimer and stirred overnight at room temperature. The mixture was filtered off with suction over Celite and concentrated by evaporation. The remaining residue was purified by means of chromatography (hexane/acetic ester 2:1) (yield: 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359306B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-5553505048354ffa84a33f9a9e44629f |
| Source note | uspto-grants-2016_06 |