HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-3-phenylisoxazole-4-carboxylic acid → 5-Methyl-3-phenylisoxazole-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-3-phenylisoxazole-4-carboxylic acid | HCID 14343 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Product | 5-Methyl-3-phenylisoxazole-4-carbonyl chloride | HCID 85624 | 93% |
Reaction Steps
A mixture of 5-methyl-3-phenyl-isoxazole-4-carboxylic acid (1.0 g, 4.9 mmol, commercially available) and thionyl chloride (5 ml) was heated under reflux for 3 h. Removal of excess volatiles by evaporation afforded 5-methyl-3-phenyl-isoxazole-4-carbonyl chloride (1.01 g, 93%) as a yellow oil, which was used without further purification in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359310B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-1d2b112c089c4c7083ad7b8abb33e3d8 |
| Source note | uspto-grants-2016_06 |