反应详情

40 mg of 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)pyridin-2-amine monohydrate monohydrochloride of Example 6 is equilibrated in 0.5 mL ethanol in a vial at 25° C.±0.1 for 3 weeks equilibration time (with constant agitation). The resulting solids are collected by filtration, air-dried to remove residual excess solvent and then analyzed by X-ray powder diffraction to yield anhydrous Polymorph Form B of the monohydrochloride salt of the compound of Formula A.

1. customvial at 25° C.
2. customfor 3 weeks
3. filtrationThe resulting solids are collected by filtration
4. customair-dried
5. customto remove residual excess solvent