Trifluoroacetic acid → HCID 71231117, compound

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Reaction Steps

Intermediate L (208 mg, 0.283 mmol) was dissolved DCM (2 ml) and TFA (2 ml) was added. The mixture was stirred at rt for 1 h. Solvents evaporated and residue dissolved in water. The solution was added 1 M NaOH (2 ml) and the aqueous layer extracted with CHCl3. The combined organic layers were dried (MgSO4) and 1.2 M HCl in EtOH (2 ml) was added. Solvents were evaporated to give the HCl-salt of the title compound. Yield: 105 mg (99%); yellow-orange solid. HPLC: RT=2.68 min, 95% (254 nm, 10-40% MeCN in 0.1% TFA, 3 min, ACE) and RT=2.68 min, 94% (350 nm, 10-40% MeCN in 0.1% TFA, 3 min, ACE). 1H NMR (400 MHz, DMSO-d6): δ 3.06 (br s, 12H), 7.14 (d, J 5.2 Hz, 2H), 7.27 (s, 2H), 7.58 (d, J 5.2 Hz, 2H). LC-MS: m/z=335 (M+1).

Provenance & Evidence