HCID 67065239, compound → HCID 67065229, compound

Participants

Reaction Steps

A solution of (12) (95 mg, 0.32 mmol) in toluene (5 mL) was added to a solution of (10) (105 mg, 0.32 mmol) in the same solvent (5 mL). Tetrakis(triphenylphosphine)palladium(0) (34 mg, 0.03 mmol) was added and the resulting mixture was refluxed for 20 min. A brown precipitate was obtained which was collected upon filtration, extensively washed with toluene, and dried under vacuum, yielding the product (8) (65 mg, 53%) which was directly used without further purification in the next step. 1H NMR (500 MHz, CDCl3) δ 8.98 (s, 1H), 8.88 (d, J=4.9 Hz, 1H), 8.65 (d, J=5.1 Hz, 1H), 8.48 (s, 1H), 7.90 (d, J=4.2 Hz, 1H), 7.48 (d, J=16.1 Hz, 1H), 7.37 (d, J=4.4 Hz, 1H), 6.93 (d, J=16.2 Hz, 1H), 6.35 (s, 1H), 4.36-4.34 (m, 2H), 4.28-4.26 (m, 2H), 4.00 (s, 3H).

Provenance & Evidence