2-(Methoxymethyl)-2'-methylbiphenyl-4-carboxylic acid → HCID 67529139, compound

Participants

Reaction Steps

The title compound was prepared following procedure described for example 4, step 1, but starting from Intermediate 28 (78.31 mg; 0.31 mmol) and Intermediate 57 (74 mg; 0.31 mmol). The reaction mixture was filtered through a SPE NH2 column (2 g) and rinsed with ACN. The filtrate was passed through a SPE SCX column (2 g) and rinsed with ACN. After evaporation of the solvents, the crude product was purified by flash chromatography (c-hex/(DCM/EtOAc 1:1) gradient from 1:0 to 1:1). The white solid was washed with MeOH affording the title compound as an off-white powder. LC/MS (Method B): 463.2 (M+H)+. HPLC (Method A) Rt 6.16 min (Purity: 97.9%).

Provenance & Evidence