3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → HCID 86305696, compound

HRID 2199598Notes

Reaction equation

HRID 2199598 reaction equation
[NH:1]([C:3]1[CH:8]=[C:7]([O:9][CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].O=[C:18]1[CH2:22][S:21][CH2:20][CH:19]1[C:23](OC)=[O:24].C(C1C=CN=C(N2C([O-])=C3CSCC3=N2)C=1)C.[Na+:44]>>[N:13]1[CH:14]=[CH:15][CH:16]=[C:11]([CH2:10][O:9][C:7]2[CH:6]=[CH:5][N:4]=[C:3]([N:1]3[C:23]([O-:24])=[C:19]4[CH2:20][S:21][CH2:22][C:18]4=[N:2]3)[CH:8]=2)[CH:12]=1.[Na+:44]

Participants

4

Reactant 3

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 67454681HCID 67454681, compoundHCID 86305741HCID 86305741, compound

Product 1

HCID 86305696HCID 86305696, compound

Procedure

According to the process described in Example 8, starting with 197 mg of 2-hydrazinyl-4-(pyridin-3-ylmethoxy)pyridine and 146 mg of methyl 4-oxotetrahydrothiophene-3-carboxylate, 225 mg of sodium 2-(4-ethylpyridin-2-yl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-olate are obtained in the form of a white lyophilizate.

Workup

  1. customare obtained in the form of a white lyophilizate

Sources & evidence

ORD record
ord-be1d6ed8bf5f48abbf862deea66836cb
Source dataset
uspto-grants-2016_06
Patent number
US09359329B2

Reaction notes

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