Hydrochloric Acid → HCID 59495716, compound

Participants

Reaction Steps

A 5N aqueous solution of NaOH (0.52 mL, 2.62 mmol) was added to a suspension of methyl 2-fluoro-4-{5-[3-(methoxymethyl)-4-(2-methylpiperidin-1-yl)phenyl]-1,2,4-oxadiazol-3-yl}benzoate (230 mg, 0.52 mmol, obtained in Example 113) in MeOH (5 mL). The resulting mixture was stirred at RT for 30 minutes. The reaction mixture was acidified with a 1N aqueous solution of HCl until pH=4 and diluted with water. The precipitate was filtered off, washed with water (3×) and dried under reduced pressure to give the title compound as a white powder. HPLC (Method A), Rt: 3.79 min (purity: 99.5%). LC/MS, M+(ESI): 426.2, M−(ESI): 424.3.

Provenance & Evidence