HCID 46244530, compound → HCID 46833478, compound

Participants

Reaction Steps

A solution of 470 mg (0.54 mmol) of 6 N-cyclopentyl-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-6-(3-oxo-4,6-dihydro-1H-thieno[3,4-c]pyrazol-2(3H)-yl)pyridine-3-sulfonamide in 1 mL of AcOH is heated at 80° C. for 4 hours. The medium is concentrated under reduced pressure and then purified by reverse-phase chromatography on a C18 column, eluting with a 10−3N HCl/CH3CN gradient of from 0 to 100% CH3CN. 48 mg of N-cyclopentyl-N-(2,3-dihydroxypropyl)-6-(3-oxo-4,6-dihydro-1H-thieno[3,4-c]pyrazol-2(3H)-yl)pyridine-3-sulfonamide are obtained in the form of a white solid.

Provenance & Evidence