2-Bromo-4-chloro-1-[(2,2-diethoxyethyl)thio]benzene → 1236538-59-2

Temperature

120 °C

In a round-bottomed flask fitted with a reflux condenser and addition funnel, a mixture of chlorobenzene (11 mL) and polyphosphoric acid (7 g) was heated to reflux. A solution of 2-bromo-1-[(2,2-diethoxyethyl)thio]-4-chlorobenzene in chlorobenzene (10 mL) was added dropwise via addition funnel then the mixture was refluxed overnight. The viscous mixture was decanted while hot. Additional chlorobenzene (25 mL) was added to the flask, stirred at 120° C. for 15 minutes, then decanted. The remaining viscous mixture in the flask was treated with toluene (50 mL), water (25 mL), and saturated Na2CO3 (aq) (10 mL). The resulting layers were separated, and the aqueous phase was extracted with toluene. The toluene and chlorobenzene fractions were combined, washed with saturated Na2CO3 (aq), then saturated NaCl (aq), dried over Na2SO4, filtered, then concentrated. The residue was purified by silica gel chromatography eluting with 0-10% EtOAc/hexanes to afford the title compound as a white solid. 1H NMR (500 MHz, CDCl3) δ 7.78 (d, J=1.5 Hz, 1H); 7.59 (d, J=5.5 Hz, 1H); 7.53 (d, J=1.5 Hz, 1H); 7.39 (d, J=5.5 Hz, 1H).

1. customIn a round-bottomed flask fitted with a reflux condenser and addition funnel
2. temperaturewas heated to reflux
3. temperaturethe mixture was refluxed overnight
4. customThe viscous mixture was decanted while hot
5. additionAdditional chlorobenzene (25 mL) was added to the flask
6. customdecanted
7. additionThe remaining viscous mixture in the flask was treated with toluene (50 mL), water (25 mL), and saturated Na2CO3 (aq) (10 mL)
8. customThe resulting layers were separated
9. extractionthe aqueous phase was extracted with toluene
10. washwashed with saturated Na2CO3 (aq)
11. dry with materialsaturated NaCl (aq), dried over Na2SO4
12. filtrationfiltered
13. concentrationconcentrated
14. customThe residue was purified by silica gel chromatography
15. washeluting with 0-10% EtOAc/hexanes

ORD record

ord-3cd682f5cd97478db07918b7f5e03a4b

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09359339B2