HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → (4-Bromo-3-trifluoromethyl-phenyl)-morpholin-4-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | (4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone | HCID 62155530 | — |
| Solvent | Water | HCID 962 | — |
| Product | (4-Bromo-3-trifluoromethyl-phenyl)-morpholin-4-yl-methanone | HCID 68941524 | — |
Reaction Steps
To a mixture of EXAMPLE 144B (8.3 g) was added water (75 mL) and H2SO4 (25 mL). The mixture was stirred at 0° C. while NaNO2 (3.13 g) in water (30 mL) was added. After stirring for 1 hour, the mixture was added to CuBr (5.45 g) in 48% HBr (200 mL). This mixture was stirred at 60° C. for 3 hours, cooled to room temperature, and partitioned between water and ethyl acetate. The organic layer was washed with aqueous Na2CO3 and dried (Na2SO4), filtered and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359296B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-b85f67f6aad84585abbb676ab5d92dee |
| Source note | uspto-grants-2016_06 |