HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86729992, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-methyl-2H-1,2,3,4-tetrazol-5-amine | HCID 138677 | — |
| Reactant | 5-Bromo-2-chloropyridine | HCID 2734414 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86729992 | HCID 86729992 | 1.5% |
Reaction Steps
2-methyl-2H-tetrazole-5-amine (7.7 g, 78 mmol), 2-chloro-5-bromopyridine (10 g, 52 mmol), and potassium tert-butylate (11.6 g, 104 mmol) were dissolved in 100 mL THF, heated under reflux and reacted for 12 h. Water was added, extracted with ethyl acetate, and the organic phase was dried, concentrated, and the solid was separated by a silica gel column (dichloromethane:methanol=100:1) to obtain 5-bromo-N-(2-methyl-2H-tetrazol-5-yl)pyridine-2-amine 200 mg, at a yield of 1.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09359344B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-fdb8d23ed5c4422cb1d7394e46bd77ad |
| Source note | uspto-grants-2016_06 |